Association of NEFL Gene Polymorphisms with Wilms’ Tumor Susceptibility in Chinese Children
Table 1
Associations between NEFL gene polymorphisms and Wilms' tumor susceptibility.
Genotype
Cases
Controls
Crude OR
P
Adjusted
(N=144)
(N=531)
(95% CI)
(95% CI)
rs11994014 G>A (HWE=0.258)
GG
59 (40.97)
186 (35.03)
1.00
1.00
AG
72 (50.00)
267 (50.28)
0.85 (0.58-1.26)
0.417
0.85 (0.57-1.26)
0.422
AA
13 (9.03)
78 (14.69)
0.53 (0.27-1.01)
0.055
0.52 (0.27-1.01)
0.052
Additive
0.150
0.77 (0.58-1.02)
0.065
0.76 (0.58-1.02)
0.063
Dominant
85 (59.03)
345 (64.97)
0.188
0.78 (0.53-1.13)
0.189
0.78 (0.53-1.14)
0.191
Recessive
131 (90.97)
453 (85.31)
0.078
0.58 (0.31-1.07)
0.081
0.57 (0.31-1.06)
0.076
rs2979704 T>C (HWE=0.245)
TT
58 (40.28)
184 (34.65)
1.00
1.00
CT
74 (51.39)
268 (50.47)
0.88 (0.59-1.30)
0.508
0.87 (0.59-1.29)
0.499
CC
12 (8.33)
79 (14.88)
0.48 (0.25-0.95)
0.034
0.48 (0.24-0.94)
0.031
Additive
0.099
0.76 (0.57-1.00)
0.052
0.75 (0.57-0.999)
0.049
Dominant
86 (59.72)
347 (65.35)
0.212
0.79 (0.54-1.15)
0.212
0.78 (0.54-1.15)
0.207
Recessive
132 (91.67)
452 (85.12)
0.041
0.52 (0.28-0.98)
0.045
0.51 (0.27-0.97)
0.041
rs1059111 A>T (HWE=0.275)
AA
58 (40.28)
185 (34.84)
1.00
1.00
AT
70 (48.61)
267 (50.28)
0.84 (0.56-1.24)
0.375
0.84 (0.56-1.25)
0.380
TT
16 (11.11)
79 (14.88)
0.65 (0.35-1.19)
0.163
0.63 (0.34-1.18)
0.148
Additive
0.344
0.81 (0.62-1.08)
0.146
0.81 (0.61-1.07)
0.136
Dominant
86 (59.72)
346 (65.16)
0.228
0.79 (0.54-1.16)
0.228
0.79 (0.54-1.16)
0.226
Recessive
128 (88.89)
452 (85.12)
0.249
0.72 (0.40-1.27)
0.251
0.70 (0.40-1.25)
0.228
Combined effect of protective genotypes
0-2
133 (92.36)
455 (85.69)
1.00
3
11 (7.64)
76 (14.31)
0.034
0.50 (0.26-0.96)
0.037
0.49 (0.25-0.95)
0.035
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium. test for genotype distributions between Wilms' tumor patients and cancer-free controls. for age and gender. genotypes were rs11994014 AA, rs2979704 CC, and rs1059111 TT.
