Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

Table 3

Immunohistochemical profile of gastrointestinal carcinoma with plasmacytoid morphology included in the study.

Biomarker group	Biomarker name	Case number
		Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Plasmacytoid differentiation	CD138	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	CD38	Focal positive	Focal positive	Negative	Focal positive	Positive	Positive	Positive
Epithelial origin	CK AE1/AE3	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	CK7	Negative	Positive	Negative	Positive	Positive	Positive	Positive
	CK20	Positive	Negative	Negative	Negative	Negative	Negative	Negative
	CDX2	Positive	Negative	Negative	Negative	Negative	Negative	Negative
	CEA	Positive	Negative	Negative	Negative	Negative	Negative	Negative
Microsatellite status	MLH-1	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	MSH-2	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	PMS-2	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	MSH-6	Positive	Positive	Positive	Positive	Positive	Positive	Positive
Epithelial-mesenchymal transition (EMT)	SLUG	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	E-cadherin	Negative	Positive	Negative	Negative	Negative	Negative	Negative
	N-cadherin	Negative	Negative	Negative	Negative	Negative	Negative	Negative
	β-catenin	Positive - Nuclear	Positive - membrane	Negative	Negative	Positive -membrane	Negative	Negative
	Vimentin	Negative	Negative	Positive	Positive	Positive	Negative	Negative
	VSIG	Focal positive	Positive	Positive - cytoplasm	Positive	Positive - membrane	Positive - cytoplasm	Positive
	CD44	Positive >25%	Negative	Positive >50%	Positive >50%	Positive >50%	Negative	Negative
	Arylsulfatase A	Positive	Positive	Positive	Positive	Positive	Positive	Negative
	Arylsulfatase B	Positive	Positive	Positive	Negative	Positive	Positive	Positive
	SMA	Negative	Negative	Negative	Negative	Negative	Negative	Negative
	EMT subtype	Mesenchymal	Epithelial	Mesenchymal	Mesenchymal	Mesenchymal	Hybrid	Mesenchymal
Angiogenesis	Maspin	Negative	Negative	Negative	Negative	Negative	Negative	Nuclear
	VEGF-A	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Differential diagnosis
Neuroendocrine markers	Chromogranin, NSE, synaptophysin	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Lymphoid differentiation	CD20, CD3, LCA, CD15	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Breast origin	Mammaglobin, GATA3	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Melanoma origin	S100, HMB45	Negative	Negative	Negative	Negative	Negative	Negative	Negative
Predictive markers	c-MET	Positive	Positive	Positive	Positive	Positive	Positive	Positive
	HER-2	Negative	Negative	Negative	Negative	Negative	Negative	Negative
	C-KIT	Negative	Negative	Negative	Negative	Negative	Negative	Negative
	NGAL	Negative	Negative	Negative	Negative	Negative	Negative	Negative
	CD10	Negative	Negative	Negative	Negative	Negative	Negative	Negative