Role of miR-221/222 in Tumor Development and the Underlying Mechanism

Figure 6

The main targets of miR-221/222 involved in ovarian cancer. Overexpression of miR-222 inhibits SOCS3 in progression of EOC, and downregulation of SOCS3 increased expression of STAT3 activation, inducing activation of JAK/STAT pathway, which increased M2 macrophages and promoted angiogenesis in tumor microenvironment. Upregulated miR-222 inhibits GNAI2 expression, which inhibited AKT phosphorylation to reduce the proliferation of ovarian cancer cells.