Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer
Table. 1
Clinical and histopathologic characteristics.
Characteristics
Study population (n = 1848)
PgR low (n = 895)
PgR high (n = 953)
value
Ki-67 low (n = 1625)
Ki-67 high (n = 223)
value
Age, mean (range)
52.2 (20–81)
49.2 (22–85)
<0.001
50.9 (22–82)
48.6 (20–85)
<0.001
Menopausal status
<0.001
0.191
Premenopausal
413 (46.2)
604 (63.4)
884 (54.4)
133 (59.6)
Postmenopausal
463 (51.7)
324 (34.0)
704 (43.3)
83 (37.2)
Unknown
19 (2.1)
25 (2.6)
37 (2.3)
7 (3.1)
Histologic type
0.147
0.183
IDCa
830 (92.7)
860 (90.2)
1479 (91.0)
211 (94.6)
ILCa
30 (3.4)
46 (4.8)
71 (4.4)
5 (2.2)
Others
35 (3.9)
47 (4.9)
75 (4.6)
7 (3.1)
Tumor size (cm)
<0.001
<0.001
≤2
452 (50.5)
564 (59.2)
919 (56.6)
97 (43.5)
>2
443 (49.5)
389 (40.8)
706 (43.4)
126 (56.5)
LN metastasis
<0.001
0.007
Negative
541 (60.4)
693 (72.7)
1103 (67.9)
131 (58.7)
Positive
354 (39.6)
260 (27.3)
522 (32.1)
92 (41.3)
Histologic grade
<0.001
<0.001
Low (I, II)
565 (66.6)
727 (76.3)
1243 (76.5)
80 (35.9)
High (III)
299 (33.4)
226 (23.7)
382 (23.5)
143 (64.1)
Breast operation
0.001
0.443
Partial mastectomy
511 (57.1)
618 (64.8)
998 (61.4)
131 (58.7)
Total mastectomy
384 (42.9)
335 (35.2)
627 (38.6)
92 (41.3)
Axilla operation
<0.001
0.290
Sentinel node biopsy
491 (54.9)
643 (67.5)
1005 (61.8)
129 (57.8)
Axilla node dissection
404 (45.1)
303 (31.8)
613 (37.7)
94 (42.2)
Not done
0 (0.0)
7 (0.7)
7 (0.4)
0 (0.0)
Recurrence
0.043
<0.001
No
861 (96.2)
935 (98.1)
1589 (97.8)
207 (92.8)
Locoregional
6 (0.7)
4 (0.4)
7 (0.4)
3 (1.3)
Distant
28 (3.1)
14 (1.5)
29 (1.8)
13 (5.8)
Death
0.022
0.009
No
885 (98.9)
951 (99.8)
1618 (99.6)
218 (97.8)
Yes
9 (1.0)
2 (0.2)
6 (0.4)
5 (2.2)
Unknown
1 (0.1)
0 (0.0)
1 (0.1)
0 (0.0)
PgR: progesterone receptor, IDCa: invasive ductal carcinoma, ILCa: invasive lobular carcinoma, and LN: lymph node. Patient outcomes according to Ki-67 and PgR expression.
