Long-Term Local Injection of RAGE-Aptamer Suppresses the Growth of Malignant Melanoma in Nude Mice

Figure 1

Effects of local injection of RAGE-aptamer on G361 tumor growth (a, b) in, and body weight (c) of, nude mice. Two million G361 malignant cells were intradermally administered into the upper flank of 6-week-old female athymic nude mice. Mice received local injection of RAGE-aptamer or vehicle adjacent to the tumor. Tumor size and body weight were measured twice a week till the end of experiments. Panel A shows typical photographs of G361 tumors at 113 days after tumor inoculation. Arrowheads indicate tumors. and compared with the values of vehicle-treated mice.

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