Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center

Table 2

Univariate survival analysis by tumor location.

Prognostic Factors	PGC group (N=4,716)				DGC group (N=7,228)				PGC versus DGC
	HR	95% CI		P Value	HR	95% CI		P Value	HR	95% CI		P Value
		Lower	Upper			Lower	Upper			Lower	Upper
Age (years)
Younger (≤35)	1.00				1.00				2.20	1.50	3.22	<0.001
Middle-aged (36-65)	0.47	0.33	0.65	<0.001	0.94	0.77	1.14	0.52	1.12	1.03	1.21	0.008
Older (≥66)	0.51	0.37	0.72	<0.001	1.01	0.82	1.24	0.92	1.14	1.01	1.28	0.028
Gender
Male	1.00				1.00				1.16	1.08	1.25	<0.001
Female	1.04	0.91	1.19	0.55	1.07	0.98	1.17	0.12	1.13	0.98	1.30	0.097
Smoking status
Never smoker	1.00				1.00				1.08	0.99	1.18	0.074
Smokers	1.00	0.91	1.10	0.98	0.85	0.78	0.93	<0.001	1.27	1.15	1.41	<0.001
Current smokers	1.03	0.92	1.14	0.63	0.89	0.81	0.99	0.023	1.25	1.11	1.40	<0.001
Ex-smokers	0.94	0.82	1.09	0.41	0.72	0.60	0.86	<0.001	1.39	1.13	1.71	0.002
Alcohol consumption
Never drinkers	1.00				1.00				1.11	1.03	1.21	0.009
Drinkers	0.95	0.86	1.05	0.35	0.85	0.77	0.94	0.001	1.24	1.11	1.39	<0.001
Current drinkers	0.97	0.87	1.07	0.55	0.90	0.82	1.00	0.048	1.19	1.06	1.34	0.004
Ex-drinkers	0.82	0.62	1.07	0.14	0.58	0.45	0.74	<0.001	1.55	1.08	2.23	0.017
BMI (kg/m2)
<18.5	1.24	1.02	1.51	0.033	1.12	0.96	1.32	0.16	1.33	1.06	1.68	0.016
18.5-22.9	1.00				1.00				1.21	1.09	1.34	<0.001
23-27.4	0.73	0.65	0.82	<0.001	0.82	0.75	0.91	<0.001	1.07	0.96	1.19	0.22
≥27.5	0.79	0.67	0.92	0.0024	0.73	0.63	0.85	<0.001	1.30	1.08	1.57	0.006
H. pylori
No	1.00				1.00				1.55	1.09	2.21	0.016
Yes	1.45	1.01	2.08	0.044	1.71	1.25	2.33	0.001	1.31	0.95	1.81	0.095
Unknown	2.36	1.80	3.09	<0.001	3.31	2.60	4.21	<0.001	1.10	1.03	1.18	0.005
Pathologic T stage
T0+Tis	3.28	0.79	13.58	0.10	2.58	0.94	7.08	0.066	2.46	0.45	13.53	0.30
T1	1.00				1.00				2.07	1.39	3.10	<0.001
T2	1.58	1.02	2.45	0.041	3.26	2.38	4.46	<0.001	0.96	0.67	1.38	0.84
T3	3.86	2.77	5.38	<0.001	8.32	6.39	10.83	<0.001	0.92	0.80	1.06	0.26
T4	6.69	4.83	9.28	<0.001	12.61	9.81	16.21	<0.001	1.05	0.95	1.15	0.37
TX	11.12	7.99	15.48	<0.001	27.37	21.21	35.31	<0.001	0.81	0.72	0.92	<0.001
Pathologic N stage
N0	1.00				1.00				1.65	1.35	2.02	<0.001
N1	1.91	1.56	2.36	<0.001	2.39	1.96	2.90	<0.001	1.31	1.07	1.60	<0.001
N2	2.84	2.34	3.44	<0.001	3.89	3.26	4.65	<0.001	1.20	1.01	1.41	0.034
N3	5.00	4.20	5.95	<0.001	8.42	7.21	9.83	<0.001	0.97	0.86	1.08	0.56
NX	6.56	5.51	7.81	<0.001	12.60	10.79	14.73	<0.001	0.85	0.76	0.96	0.007
Pathologic M stage
M0	1.00				1.00				1.28	1.18	1.38	<0.001
M1	4.96	4.33	5.68	<0.001	7.45	6.73	8.25	<0.001	0.85	0.73	0.98	0.027
pTNM
0	4.06	0.99	16.71	0.052	2.25	0.71	7.14	0.17	3.16	0.53	19.05	0.21
I	1.00				1.00				2.04	1.42	2.94	<0.001
II	2.26	1.63	3.15	<0.001	4.43	3.35	5.86	<0.001	1.03	0.81	1.29	0.84
III	6.39	4.79	8.52	<0.001	12.28	9.64	15.64	<0.001	1.03	0.94	1.12	0.58
IV	23.33	17.19	31.68	<0.001	54.77	42.63	70.38	<0.001	0.85	0.73	0.98	0.027
Lauren classification
Intestinal	1.00				1.00				1.68	1.31	2.15	<0.001
Diffuse	1.93	1.54	2.42	<0.001	2.09	1.66	2.62	<0.001	1.54	1.25	1.90	<0.001
Mixed	1.54	1.22	1.94	0.0003	1.37	1.04	1.81	0.024	1.88	1.45	2.46	<0.001
Unknown	2.76	2.35	3.24	<0.001	4.45	3.64	5.44	<0.001	1.05	0.97	1.13	0.22
Stage
Early stage	1.00				1.00				2.09	1.31	3.32	0.002
LAGC	5.29	3.65	7.65	<0.001	9.18	7.24	13.04	<0.001	1.09	1.01	1.19	0.032
Distant	25.33	17.25	37.20	<0.001	60.25	44.52	81.52	<0.001	0.85	0.73	0.98	0.027
Type of gastrectomy
Gastrectomy	1.00				1.00				1.24	1.15	1.34	<0.001
No surgery	3.01	2.71	3.35	<0.001	4.47	4.08	4.88	<0.001	0.84	0.74	0.94	0.002
Surgical Margin
Negative	1.00				1.00				1.27	1.17	1.38	<0.001
Positive on the proximal margin	1.96	1.34	2.87	0.0006	2.98	2.07	4.28	<0.001	0.81	0.48	1.37	0.43
Positive on the distal margin	2.49	1.63	3.79	<0.001	2.56	1.85	3.53	<0.001	1.25	0.74	2.12	0.40
Positive on the proximal and distal margin	1.08	0.27	4.34	0.91	2.57	1.33	4.95	0.005	0.60	0.13	2.80	0.51
HER2 score
0 (-)	1.00				1.00				1.45	1.22	1.73	<0.001
1 (+)	0.70	0.57	0.86	0.001	0.85	0.72	1.02	0.073	1.19	0.98	1.46	0.083
2 (++)	0.69	0.53	0.89	0.005	0.66	0.51	0.85	0.002	1.54	1.11	2.12	0.01
3 (+++)	0.94	0.71	1.26	0.68	0.99	0.72	1.38	0.96	1.38	0.93	2.07	0.11
Unknown	1.72	1.49	1.98	<0.001	2.44	2.15	2.77	<0.001	1.03	0.95	1.11	0.49
Linitis plastica
No	1.00				1.00				1.15	1.08	1.23	<0.001
Yes	2.44	1.44	4.12	0.001	2.37	1.63	3.44	<0.001	1.22	0.64	2.33	0.54
Borrmann classification
Borrmann I	1.00				1.00				1.03	0.78	1.35	0.85
Borrmann II	1.03	0.85	1.24	0.79	0.93	0.73	1.17	0.52	1.14	1.00	1.30	0.045
Borrmann III	1.14	0.94	1.38	0.20	1.13	0.90	1.43	0.30	1.03	0.90	1.17	0.71
Borrmann IV	2.16	1.70	2.75	<0.001	2.11	1.63	2.73	<0.001	1.05	0.84	1.31	0.67
Unknown	2.44	1.99	3.01	<0.001	3.09	2.44	3.93	<0.001	0.81	0.69	0.94	0.007
Location
PGC	1.00
DGC	0.87	0.82	0.93	<0.001