Research Article

Nomogram for Predicting Recurrence-Free Survival in Chinese Women with Endometrial Cancer after Initial Therapy: External Validation

Table 2

Multivariate Cox proportional hazards regression analysis for recurrence-free survival (RFS) in the training cohort.

VariablesUnivariate analysis valueMultivariate analysis value
OR (95% CI)Adjusted OR (95% CI)

Age (years)
 <601 (referent)
 ≥602.4 (1.3–4.3)0.003

Depth of myometrial invasion
 <50%1 (referent)
 ≥50%2.9 (1.6–5.2)<0.001

Cervical stromal invasion
 No1 (referent)
 Yes4.1 (2.2–7.6)<0.001

Histological grade
 Grade 1/21 (referent)1 (referent)
 Grade 39.4 (5.0–18.0)<0.0014.2 (2.1–8.4)<0.001

Histological type
 Type I1 (referent)
 Type II8.5 (4.7–15.2)<0.001

Tumor diameter
 <2 cm1 (referent)1 (referent)
 ≥2 cm6.6 (2.4–18.4)<0.0012.9 (1.0–8.4)0.049

LVSI
 No1 (referent)
 Yes4.1 (2.2–7.5)<0.001

FIGO stage
 I1 (referent)1 (referent)
 II5.4 (2.0–14.3)0.0012.4 (0.9–6.7)0.099
 III8.8 (4.1–19.0)<0.0014.2 (1.9–9.5)<0.001
 IV84.3 (36.3–195.5)<0.00115.1 (5.4–42.8)<0.001

Peritoneal cytology
 No1 (referent)1 (referent)
 Yes10.1 (5.6–18.3)<0.0012.5 (1.2–5.0)0.013

Lymph node involvement
 No1 (referent)
 Yes8.1 (4.2–15.5)<0.001

Lymphadenectomy
 No1 (referent)
 Yes0.7 (0.3–1.4)0.27

Adjuvant therapy
 No adjuvant therapy1 (referent)
 Radiotherapy9.6 (2.0–45.6)0.004
 Chemotherapy6.7 (3.0–14.7)<0.001
 Radiotherapy + chemotherapy5.3 (2.0–14.1)<0.001

OR = odds ratio; CI = confidence interval; LVSI = lymphovascular space involvement; FIGO = International Federation of Gynecology and Obstetrics.