Research Article
Nomogram for Predicting Recurrence-Free Survival in Chinese Women with Endometrial Cancer after Initial Therapy: External Validation
Table 2
Multivariate Cox proportional hazards regression analysis for recurrence-free survival (RFS) in the training cohort.
| Variables | Univariate analysis | value | Multivariate analysis | value | OR (95% CI) | Adjusted OR (95% CI) |
| Age (years) | | | | | <60 | 1 (referent) | | | | ≥60 | 2.4 (1.3–4.3) | 0.003 | | |
| Depth of myometrial invasion | | | | | <50% | 1 (referent) | | | | ≥50% | 2.9 (1.6–5.2) | <0.001 | | |
| Cervical stromal invasion | | | | | No | 1 (referent) | | | | Yes | 4.1 (2.2–7.6) | <0.001 | | |
| Histological grade | | | | | Grade 1/2 | 1 (referent) | | 1 (referent) | | Grade 3 | 9.4 (5.0–18.0) | <0.001 | 4.2 (2.1–8.4) | <0.001 |
| Histological type | | | | | Type I | 1 (referent) | | | | Type II | 8.5 (4.7–15.2) | <0.001 | | |
| Tumor diameter | | | | | <2 cm | 1 (referent) | | 1 (referent) | | ≥2 cm | 6.6 (2.4–18.4) | <0.001 | 2.9 (1.0–8.4) | 0.049 |
| LVSI | | | | | No | 1 (referent) | | | | Yes | 4.1 (2.2–7.5) | <0.001 | | |
| FIGO stage | | | | | I | 1 (referent) | | 1 (referent) | | II | 5.4 (2.0–14.3) | 0.001 | 2.4 (0.9–6.7) | 0.099 | III | 8.8 (4.1–19.0) | <0.001 | 4.2 (1.9–9.5) | <0.001 | IV | 84.3 (36.3–195.5) | <0.001 | 15.1 (5.4–42.8) | <0.001 |
| Peritoneal cytology | | | | | No | 1 (referent) | | 1 (referent) | | Yes | 10.1 (5.6–18.3) | <0.001 | 2.5 (1.2–5.0) | 0.013 |
| Lymph node involvement | | | | | No | 1 (referent) | | | | Yes | 8.1 (4.2–15.5) | <0.001 | | |
| Lymphadenectomy | | | | | No | 1 (referent) | | | | Yes | 0.7 (0.3–1.4) | 0.27 | | |
| Adjuvant therapy | | | | | No adjuvant therapy | 1 (referent) | | | | Radiotherapy | 9.6 (2.0–45.6) | 0.004 | | | Chemotherapy | 6.7 (3.0–14.7) | <0.001 | | | Radiotherapy + chemotherapy | 5.3 (2.0–14.1) | <0.001 | | |
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OR = odds ratio; CI = confidence interval; LVSI = lymphovascular space involvement; FIGO = International Federation of Gynecology and Obstetrics.
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