Research Progress on Slit/Robo Pathway in Pancreatic Cancer: Emerging and Promising

Table 1

Summary of Slit/Robo pathway expression and function in PDAC.

Author	Gene	Expression	Function	Metastasis
Gohrig et al. [38]	Slit2	Downregulation	Tumor and invasion suppressor	Suppress
He et al. [40]	Robo1	Upregulation	Promote the lymphatic metastasis of pancreatic cancer	Promote
Pinho et al. [41]	Robo1	Upregulation	Corresponding to poor prognosis	—
Pinho et al. [41]	Robo2	Downregulation	Stroma suppressor gene	Suppress
Biankin et al. [12]	Robo2	Downregulation	Tumor suppressor and high expression is associated with better prognosis	Suppress
Biankin et al. [12]	Robo3	Upregulation	Associated with poor prognosis	Promote
Han et al. [39]	Robo2	Downregulated with tumor stage	—	—
Han et al. [39]	Robo3	Upregulated with tumor stage	Promote growth and metastasis of pancreatic cancer	Promote