Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Table 3

Univariable analysis of clinicopathologic variables in relation to OS and DFS in RCC patients.

Parameter	OS		DFS
	HR (95% CI)		HR (95% CI)
Age (years)		0.026		0.050
<65	1 (referent)		1 (referent)
≥65	1.984 (1.085 – 3.627)		1.783 (1.000 – 3.181)
Gender		0.100		0.341
Male	1 (referent)		1 (referent)
Female	0.546 (0.266 – 1.123)		0.740 (0.399 – 1.374)
BMI (kg/m^2)		0.226		0.829
≥24	1 (referent)		1 (referent)
<24	1.426 (0.803 – 2.534)		1.060 (0.626 – 1.793)
HGB (g/L)		0.001		0.004
≥120	1 (referent)		1 (referent)
<120	2.588 (0.224 – 0.681)		2.201 (1.296 – 3.740)
Ca (mmol/L)		0.019		0.134
<2.4	1 (referent)		1 (referent)
≥2.4	2.134 (1.468 – 4.457)		1.630 (0.860 – 3.087)
Creatinine (μmoI/L)		0.060		0.075
<90	1 (referent)		1 (referent)
≥90	1.700 (0.979 – 2.952)		1.609 (0.953 – 2.716)
Ccr (ml/min)		<0.001		0.001
>80	1 (referent)		1 (referent)
≤80	2.968 (1.670 – 5.274)		2.466 (1.452 – 4.188)
Basic disease		0.425		0.381
No	1 (referent)		1 (referent)
Yes	1.277 (0.707 – 2.307)		1.284 (0.734 – 2.244)
Symptom		0.001		0.001
No	1 (referent)		1 (referent)
Yes	2.751 (1.487 – 5.090)		2.718 (1.525 – 4.845)
Surgery		0.001		0.002
Endoscopic	1 (referent)		1 (referent)
Open	2.613 (1.503 – 4.537)		2.269 (1.336 – 3.855)
Site		0.640		0.524
Left	1 (referent)		1 (referent)
Right	0.876 (0.503 – 1.525)		0.843 (0.498 – 1.426)
Tumour size (D/cm)		<0.001		<0.001
<7	1 (referent)		1 (referent)
≥7	5.352 (3.010 – 9.517)		4.196 (2.475 – 7.113)
Tumour necrosis		0.779		0.156
Absent	1 (referent)		1 (referent)
Present	0.924 (0.530 – 1.608)		0.677 (0.395 – 1.161)
Tumour type		<0.001		<0.001
ccRCC	1 (referent)		1 (referent)
nccRCC	3.235 (1.858 – 5.634)		3.080 (01.821 – 5.208)
TNM stage		<0.001		<0.001
I	1 (referent)		1 (referent)
II	4.210 (1.951 – 9.086)		3.375 (1.678 – 6.790)
III	9.848( 4.612 – 21.026)		8.305 (4.164 – 16.562)
IV	13.634 (6.088 – 30.531)		10.427 (4.787 – 22.713)
Fuhrman grade		<0.001		<0.001
G1 + G2	1 (referent)		1 (referent)
G3 + G4	4.548 (2.455 – 8.424)		3.250 (1.885 – 5.603)
RLR		<0.001		<0.001
<8.6	1 (referent)		1 (referent)
≥8.6	3.350 (1.923 – 5.834)		3.012 (1.783 – 5.077)
AFR		<0.001		<0.001
≥9	1 (referent)		1 (referent)
<9	6.816 (3.729 – 12.458)		5.957 (3.428 – 10.350)