Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

Table 4

Multivariable analysis of clinicopathologic variables in relation to OS and DFS in RCC patients.

Parameter	OS		DFS
	HR (95% CI)	P	HR (95% CI)	P
Symptom		0.036		0.020
No	1 (referent)		1 (referent)
Yes	2.027 (1.046 – 3.927)		2.051 (1.117 – 3.764)
Tumour type		<0.001		<0.001
ccRCC	1 (referent)		1 (referent)
nccRCC	4.445 (2.387 – 8.279)		2.834 (1.652 – 4.859)
TNM stage		<0.001		<0.001
I	1 (referent)		1 (referent)
II	2.816 (1.268 – 6.256)		2.118 (1.032 – 4.349)
III	5.994 (2.604 – 13.800)		4.161 (1.954 – 8.861)
IV	9.980 (4.039 – 24.657)		6.253 (2.649 – 14.759)
Fuhrman grade		<0.001		0.003
G1 + G2	1 (referent)		1 (referent)
G3 + G4	3.409 (1.817 – 6.705)		2.326 (1.323 – 4.090)
RLR		0.007		0.013
<8.6	1 (referent)		1 (referent)
≥8.6	2.255 (1.242 – 4.093)		1.969 (1.152 – 3.367)
AFR		0.019		0.008
≥9	1 (referent)		1 (referent)
<9	2.349 (1.153 – 4.787)		2.357 (1.254 – 4.433)