Potential Functional Variants in DNA Repair Genes Are Associated with Efficacy and Toxicity of Radiotherapy in Patients with Non-Small-Cell Lung Cancer

Table 2

Association between candidate SNPs and efficacy of radiotherapy.

Gene		SNPs	Genotype	CR + PR	SD + PD	OR (95% CI)
XRCC1		rs25487	CC	130	111	Reference	Reference
			CT	81	98	0.706 (0.479–1.041)	0.078
			TT	23	43	0.457 (0.259–0.804)	0.006
			CT + TT	104	141	0.630 (0.440–0.901)	0.011
		rs25489	CC	190	203	Reference	Reference
			CT	42	47	0.955 (0.602–1.514)	0.844
			TT	2	2	1.068 (0.149–7.661)	0.947
			CT + TT	44	49	0.959 (0.610–1.509)	0.858
		rs1799782	GG	128	121	Reference	Reference
			AG	84	97	0.819 (0.558–1.201)	0.306
			AA	22	34	0.612 (0.339–1.105)	0.101
			AG + AA	106	131	0.765 (0.535–1.093)	0.141
		rs3213245	AA	182	181	Reference	Reference
			AG	53	66	0.799 (0.527–1.211)	0.289
			GG	3	5	0.597 (0.141–2.534)	0.479
			AG + GG	56	71	0.784 (0.523–1.178)	0.241
XRCC2		rs3218544	GG	82	78	Reference	Reference
			AG	114	133	0.815 (0.547–1.214)	0.315
			AA	38	41	0.882 (0.514–1.512)	0.647
			AG + AA	152	174	0.831 (0.569–1.214)	0.338
		rs3218385	AA	172	172	Reference	Reference
			AC	53	73	0.726 (0.481–1.096)	0.127
			CC	9	7	1.286 (0.468–3.530)	0.625
			AC + CC	62	80	0.775 (0.523–1.148)	0.203
		rs3218556	GG	166	149	Reference	Reference
			AG	57	77	0.664 (0.442–0.999)	0.049
			AA	11	26	0.380 (0.181–0.795)	0.008
			AG + AA	68	103	0.593 (0.406–0.865)	0.006
MSH2		rs2303424	GG	86	102	Reference	Reference
			AG	117	129	1.076 (0.735–1.574)	0.707
			AA	31	20	1.599 (0.868–2.945)	0.131
			AG + AA	148	149	1.178 (0.817–1.699)	0.380
		rs2303425	TT	147	166	Reference	Reference
			CT	72	62	1.311 (0.874–1.968)	0.190
			CC	15	24	0.706 (0.357–1.396)	0.315
			CT + CC	87	86	1.142 (0.788–1.657)	0.483
XPD		rs238419	CC	79	95	Reference	Reference
			CT	101	110	1.104 (0.738–1.651)	0.629
			TT	54	47	1.382 (0.845–2.259)	0.197
			CT + TT	155	157	1.187 (0.818–1.722)	0.366
		rs13181	TT	176	209	Reference	Reference
			GT	56	40	1.663 (1.057–2.614)	0.027
			GG	2	3	0.792 (0.131–4.791)	0.799
			GT + GG	58	43	1.602 (1.029–2.493)	0.036

The values in bold represent a statistically significant association. All data are adjusted for age, gender, smoking history, cancer histology, family history, and treatment with chemotherapy.