Potential Functional Variants in DNA Repair Genes Are Associated with Efficacy and Toxicity of Radiotherapy in Patients with Non-Small-Cell Lung Cancer

Table 3

Association between candidate SNPs and radiation-induced toxic reactions.

Gene	SNPs	Genotype	Low toxic reactions	High toxic reactions	OR (95% CI)
XRCC1	rs25487	CC	188	74	Reference	Reference
		CT	114	69	0.650 (0.435–0.972)	0.035
		TT	23	18	0.503 (0.257–0.986)	0.043
		CT + TT	137	87	0.620 (0.424–0.907)	0.013
	rs25489	CC	257	122	Reference	Reference
		CT	65	38	0.812 (0.515–1.279)	0.369
		TT	3	1	0.424 (0.147–13.83)	0.759
		CT + TT	68	39	0.828 (0.528–1.297)	0.409
	rs1799782	GG	175	91	Reference	Reference
		AG	117	58	1.049 (0.700–1.571)	0.817
		AA	33	12	1.430 (0.705–2.902)	0.320
		AG + AA	150	70	1.114 (0.762–1.630)	0.577
	rs3213245	AA	248	117	Reference	Reference
		AG	74	43	0.812 (0.525–1.255)	0.348
		GG	3	1	1.415 (0.146–13.75)	0.764
		AG + GG	77	44	0.826 (0.537–1.270)	0.383
XRCC2	rs3218544	GG	117	49	Reference	Reference
		AG	162	83	0.817 (0.534–1.251)	0.353
		AA	46	28	0.688 (0.387–1.224)	0.202
		AG + AA	208	111	0.785 (0.523–1.177)	0.241
	rs3218385	AA	235	109	Reference	Reference
		AC	78	47	0.770 (0.502–1.180)	0.229
		CC	12	5	1.113 (0.383–3.238)	0.844
		AC + CC	90	52	0.803 (0.533–1.210)	0.293
	rs3218556	GG	238	96	Reference	Reference
		AG	78	52	0.605 (0.396–0.924)	0.019
		AA	9	13	0.279 (0.116–0.675)	0.003
		AG + AA	87	65	0.540 (0.362–0.805)	0.002
MSH2	rs2303424	GG	123	52	Reference	Reference
		AG	156	82	0.804 (0.528–1.224)	0.309
		AA	46	27	0.720 (0.405–1.280)	0.263
		AG + AA	202	109	0.783 (0.526–1.168)	0.230
	rs2303425	TT	204	106	Reference	Reference
		CT	104	45	1.201 (0.788–1.830)	0.394
		CC	17	10	0.883 (0.391–1.997)	0.765
		CT + CC	121	55	1.143 (0.769–1.698)	0.508
XPD	rs238419	CC	102	43	Reference	Reference
		CT	149	77	0.816 (0.520–1.280)	0.375
		TT	74	41	0.761 (0.451–1.283)	0.304
		CT + TT	223	118	0.797 (0.523–1.213)	0.289
	rs13181	TT	235	130	Reference	Reference
		GT	82	27	1.680 (1.035–2.728)	0.035
		GG	8	4	1.106 (0.327–3.745)	0.871
		GT + GG	90	31	1.624 (1.025–2.547)	0.038

The values in bold indicate a statistically significant association. All data are adjusted for age, gender, smoking history, cancer histology, family history, and treatment with chemotherapy.