Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer

Table 6

Stratified analyses between rs2277438 polymorphism and risk by sex, age, smoking status, and alcohol consumption.

Variable	(Case/control)			Adjusted OR (95% CI);			(AG + GG) VSAA	GGVS (AA + AG)
	AA	AG	GG	AA	AG	GG
Sex
Male	198/201	157/198	36/45	1.00	0.81 (0.60–1.07); : 0.138	0.81 (0.50–1.31); : 0.395	0.81 (0.61–1.06); : 0.121	0.90 (0.57–1.43); : 0.651
Female	86/109	79/93	17/19	1.00	1.08 (0.71–1.63); : 0.725	1.13 (0.56–2.31); : 0.729	1.09 (0.73–1.61); : 0.679	1.09 (0.55–2.18); : 0.795
Age
<62	129/146	108/138	29/31	1.00	0.89 (0.63–1.25); : 0.491	1.06 (0.61–1.85); : 0.841	0.92 (0.66–1.27); : 0.606	1.12 (0.66–1.91); : 0.675
≥62	155/164	128/153	24/33	1.00	0.89 (0.64–1.22); : 0.457	0.77 (0.44–1.36); : 0.367	0.87 (0.64–1.18); : 0.353	0.82 (0.47–1.41); : 0.464
Smoking status
Never	189/230	154/207	33/49	1.00	0.91 (0.68–1.20); : 0.492	0.82 (0.51–1.33); : 0.417	0.89 (0.68–1.16); : 0.392	0.86 (0.50–1.36); : 0.517
Ever	95/80	82/84	20/15	1.00	0.82 (0.54–1.26); : 0.367	1.12 (0.54–2.24); : 0.757	0.87 (0.58–1.30); : 0.493	1.24 (0.61–2.49); : 0.555
Alcohol consumption
Never	223/237	182/224	46/52	1.00	0.86 (0.66–1.13); : 0.283	0.94 (0.61–1.46); : 0.782	0.88 (0.68–1.31); : 0.314	1.01 (0.66–1.53); : 0.974
Ever	61/73	54/67	7/12	1.00	0.97 (0.59–1.58); : 0.886	0.70 (0.26–1.88); : 0.476	0.94 (0.58–1.51); : 0.796	0.71 (0.27–1.86); : 0.485