The Dependence between Urinary Levels of Angiogenesis Factors, 8-Iso-prostaglandin F2α, ɣ-Synuclein, and Interleukin-13 in Patients with Bladder Cancer: A Pilot Study

Table 4

Median levels and interquartile ranges of parameters in the urine of the LG (A) subgroup, HG (B) subgroup, and control group (C) with statistical analysis.

Parameters	Subgroups
	LG (A)		HG (B)		Control group (C)		value	Post hoc analysis
	Me	IQR	Me	IQR	Me	IQR
ANG (ng/mg cr.)	0.42	0.25–0.81	0.72	0.33–1.31	0.06	0.04–0.15	<0.001	A : C < 0.001; B : C < 0.001; A : B  =  NS
ANGST (ng/mg cr.)	0.41	0.24–0.71	0.54	0.45–1.13	0.08	0.06–0.16	<0.001	A : C  <  0.001; B : C  <  0.001; A : B  =  NS
8-Iso-PGF2α (ng/mg cr.)	5.15	3.10–33.48	5.07	2.72–17.60	3.44	2.74–4.58	0.03	A : C  =  0.03; B : C  = NS; A : B = NS
SNCG (pg/mg cr.)	17.11	12.67–28.61	15.32	13.97–25.97	12.41	9.06–16.07	0.002	A : C = 0.004; B : C = 0.013; A : B = NS
IL-13 (pg/mg cr.)	1.58	1.11–3.57	1.88	1.24–2.75	1.01	0.68–1.58	<0.001	A : B = 0.004; B : C = 0.002; A : B = NS

ANG: angiogenin; ANGST: angiostatin; 8-Iso-PGF2α: 8-iso-prostaglandin F2α; SNCG: ɣ-synuclein; IL-13: interleukin-13; LG: low grade; HG: high grade; Me: median; CI: confidence interval; NS: not statistically significant. Statistically significant difference between LG (A), HG (B), and control group (C) using Kruskal–Wallis test.