The Dependence between Urinary Levels of Angiogenesis Factors, 8-Iso-prostaglandin F2α, ɣ-Synuclein, and Interleukin-13 in Patients with Bladder Cancer: A Pilot Study

Table 6

Median levels and interquartile ranges of examined parameters in the urine of the BC primary cancer (A) subgroup, the cancer recurrent (B) subgroup, and the control group (C) with statistical analysis.

Parameters	Subgroups
	Primary cancer (A)		Cancer recurrent (B)		Control group (C)		value	Post hoc analysis
	Me	IQR	Me	IQR	Me	IQR
ANG (ng/mg cr.)	0.57	0.32–1.31	0.68	0.30–0.92	0.06	0.04–0.15	<0.001	A : C < 0.001; B : C < 0.001; A : B = NS
ANGST (ng/mg cr.)	0.56	0.33–1.14	0.49	0.27–0.75	0.08	0.06–0.16	<0.001	A : C < 0.001; B : C < 0.001; A : B = NS
8-Iso-PGF2α (ng/mg cr.)	4.79	3.31–32.11	5.89	2.26–19.97	3.44	2.74–4.58	0.04	A : B = NS; B : C = NS; A : B = NS
SNCG (pg/mg cr.)	16.68	13.09–27.67	15.46	13.02–23.31	12.41	9.06–16.07	0.002	A : B = 0.006; B : C = 0.009; A : B = NS
IL-13 (pg/mg cr.)	1.81	1.25–3.37	1.79	1.21–2.85	1.01	0.68–1.58	<0.001	A : B = 0.004; B : C = 0.002; A : B = NS

ANG: angiogenin; ANGST: angiostatin; 8-Iso-PGF2α: 8-iso-prostaglandin F2α; SNCG: ɣ-synuclein; IL-13: interleukin-13; NMIBC: nonmuscle-invasive bladder cancer; MIBC: muscle-invasive bladder cancer; Me: median; CI: confidence interval; NS: not statistically significant. Statistically significant difference between primary cancer (A), cancer recurrence (B), and control group (C) using Kruskal–Wallis test.