Research Article

Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2-Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Table 2

KEGG pathway analysis of differentially expressed genes.

TermCount valueGenes

hsa05150: staphylococcus aureus infection13<0.001C3AR1, C3, HLA-DRB3, FPR1, C1R, C1S, HLA-DQA1, FCGR1A, CFH, FCGR3A, CFD, SELPLG, FCGR3B
hsa04145: phagosome19<0.001MRC1, NOS1, OLR1, C3, TUBB2A, HLA-DRB3, TLR2, HLA-C, C1R, TLR6, HLA-DQA1, CYBB, CD36, FCGR1A, COMP, CLEC7A, FCGR3A, FCGR3B, THBS4
hsa04514: cell adhesion molecules (CAMs)16<0.001CLDN19, HLA-DRB3, HLA-C, L1CAM, NLGN3, CDH2, HLA-DQA1, CDH5, ALCAM, NCAM1, CD86, CD34, ITGA8, CLDN1, CD4, SELPLG
hsa04640: hematopoietic cell lineage12<0.001CR1, CD37, CD36, CD34, HLA-DRB3, FCGR1A, MME, IL1B, CD4, ANPEP, CSF2RA, CSF1R
hsa05144: malaria9<0.001CR1, CD36, COMP, TLR2, IL1B, HBA2, HBA1, HBB, THBS4
hsa04610: complement and coagulation cascades10<0.001C3AR1, VWF, CR1, C3, F13A1, CFH, TFPI, C1R, C1S, CFD
hsa04510: focal adhesion170.0017PIK3CG, EGFR, CAV1, TNXB, TNC, FLNB, MYL9, VWF, CCND1, PAK3, CCND2, COMP, ITGA8, COL6A3, PDGFRA, SPP1, THBS4
hsa04060: cytokine-cytokine receptor interaction180.0022EGFR, CCL3, TGFBR1, LIFR, EDA2R, CCL4L1, CCL4, CXCL12, IL17RA, LEP, PPBP, CXCL14, CCL3L3, CX3CR1, PDGFRA, IL1B, CSF2RA, CSF1R
hsa05140: leishmaniasis90.0027CR1, C3, HLA-DRB3, FCGR1A, TLR2, IL1B, FCGR3A, FCGR3B, HLA-DQA1
hsa04151: PI3K-akt signaling pathway230.0033EGFR, PIK3CG, FGF7, TNXB, TNC, TLR2, FGF10, IRS1, DDIT4, VWF, CCND1, LPAR5, CCND2, COMP, ITGA8, COL6A3, PDGFRA, MDM2, ANGPT1, FGF1, SPP1, THBS4, CSF1R
hsa00350: tyrosine metabolism60.0063MAOA, AOX1, ADH1C, ADH1B, ADH1A, AOC3
hsa03320: PPAR signaling pathway80.0075LPL, CD36, OLR1, PLIN1, SLC27A6, FABP4, ACADL, ADIPOQ
hsa04512: ECM-receptor interaction90.0094VWF, CD36, TNXB, COMP, TNC, ITGA8, COL6A3, SPP1, THBS4
hsa04620: Toll-like receptor signaling pathway100.0100PIK3CG, CD86, CCL3, CCL3L3, TLR2, CCL4L1, IL1B, TLR6, CCL4, SPP1
hsa05323: rheumatoid arthritis90.0101CD86, CCL3, HLA-DRB3, CCL3L3, TLR2, IL1B, ANGPT1, CXCL12, HLA-DQA1
hsa05218: melanoma80.0103PIK3CG, EGFR, CCND1, FGF7, PDGFRA, MDM2, FGF10, FGF1
hsa04015: Rap1 signaling pathway150.0126FYB, PIK3CG, EGFR, FGF7, FPR1, FGF10, APBB1IP, DOCK4, PLCB4, LPAR5, RASGRP3, PDGFRA, ANGPT1, FGF1, CSF1R
hsa05416: viral myocarditis70.0126CAV1, CD86, CCND1, HLA-DRB3, SGCD, HLA-C, HLA-DQA1
hsa04730: long-term depression70.0160PLA2G4A, PLCB4, NOS1, GRIA2, LYN, GUCY1A2, GUCY1B3
hsa05206: microRNAs in cancer180.0176EGFR, TNXB, CYP1B1, TNC, MIRLET7F1, MIR99A, ZEB1, MIR222, MIR221, IRS1, DDIT4, NOTCH3, CCND1, CCND2, PDGFRA, MDM2, MARCKS, MIR181B2
hsa05152: tuberculosis130.0178MRC1, CR1, ITGAX, C3, FCGR1A, HLA-DRB3, TLR2, IL1B, CLEC7A, FCGR3A, TLR6, FCGR3B, HLA-DQA1
hsa05205: proteoglycans in cancer140.0191PIK3CG, EGFR, CAV1, LUM, FZD1, TLR2, DCN, FLNB, CCND1, CBLB, GPC3, RRAS2, MDM2, PTCH1
hsa05143: African trypanosomiasis50.0250PLCB4, IL1B, HBA2, HBA1, HBB
hsa05332: graft-versus-host disease50.0250CD86, HLA-DRB3, IL1B, HLA-C, HLA-DQA1
hsa05142: Chagas disease (American trypanosomiasis)90.0254PIK3CG, CCL3, PLCB4, C3, TGFBR1, CCL3L3, TLR2, IL1B, TLR6
hsa05200: pathways in cancer220.0267EGFR, PIK3CG, FGF7, TGFBR1, FZD1, RUNX1T1, FGF10, CXCL12, CBLB, CCND1, PLCB4, LPAR5, RASGRP3, SLC2A1, PDGFRA, MDM2, PTCH1, PTCH2, HHIP, FGF1, CSF2RA, CSF1R
hsa04810: regulation of actin cytoskeleton140.0282PIK3CG, EGFR, FGF7, FGF10, NCKAP1L, MYL9, ARPC1B, ITGAX, CHRM3, PAK3, ITGA8, RRAS2, PDGFRA, FGF1
hsa04380: osteoclast differentiation100.0349PIK3CG, CYBB, FCGR1A, TGFBR1, IL1B, FCGR3A, TREM2, FCGR3B, CSF1R, BLNK