Research Article
Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis
Figure 1
OR cells losing sensitivity to osimertinib. (a) The in vitro cell viability assay of OR and H1975 cells after incubation with 10−5-10−9 mol/L osimertinib for 72 h detected by MTS kit (n = 6). (b) The cell apoptotic assay of H1975 and OR cells after incubation with 10−5 mol/L osimertinib for 8 h (n = 3). (c) The cell cycle arrest assay of H1975 and OR cells after incubation with 10−5 mol/L osimertinib for 8 h (n = 3). Each bar represents the mean ± S.D. , , and compared to the H1975 group.
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