Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis

<div>Differential metabolites and their corresponding pathways. (a) Heatmap of the intensities of differential metabolites in H1975 and OR cells (<i>n</i> = 3). The degree of change is marked with different colors: red indicates upregulation, and green represents downregulation. Each row represents an individual sample and each column represents a metabolite. (b) Metabolism pathways participating in osimertinib resistance and the map was generated by MetPA.</div>

Journal of Oncology

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Figure 4: Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis 

Figure 4 | Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis 