Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis

Figure 5

Five significantly altered GO pathways, after osimertinib resistance in H1975 cells. (a) The protein-protein interaction of differentially expressed proteins in response to chemical and the heatmap of intensities of those differentially expressed proteins (n = 3). (b) The protein-protein interaction of differentially expressed proteins in response to external stimulus and the heatmap of intensities of those differentially expressed proteins (n = 3). (c) The protein-protein interaction of differentially expressed proteins in regulation of cell communication and the heatmap of intensities of those differentially expressed proteins (n = 3). (d) The protein-protein interaction of differentially expressed proteins in small molecule metabolic process and the heatmap of intensities of those differentially expressed proteins (n = 3). The degree of change is marked with different colors: red indicates upregulation, and blue represents downregulation. Each row represents an individual sample and each column represents a metabolite.

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