Clinical Significance of the Interaction between Human Papillomavirus (HPV) Type 16 and Other High-Risk Human Papillomaviruses in Women with Cervical Intraepithelial Neoplasia (CIN) and Invasive Cervical Cancer
Table 3
Rates of cervical intraepithelial neoplasia (CIN) diagnoses according to the interaction between HPV type 16 and HPV33, 51, 52, and 66.
CIN 1
CIN 2
CIN 3
Invasive cancer
(n) 1811 (%)
(n) 405 (%)
(n) 678 (%)
(n) 91 (%)
Single HPV 16 (n = 491)
246 (13.6)
75 (18.5)
140 (20.6)
30 (33)
HPV16 and HPV18 negative (n = 1972)
1296 (71.6)
256 (63.2)
377 (55.6)
43 (47.2)
HPV16 and HPV18 positive (n = 99)
36 (2)
13 (3.2)
45 (6.6)
5 (5.5)
Single HPV 18 (n = 65)
42 (2.3)
9 (2.2)
11 (1.6)
3 (3.3)
Multiple HPV 16 (no HPV 18) n = 298
156 (8.6)
41 (10.1)
93 (13.7)
8 (8.9)
Multiple HPV 18 (no HPV 16) n = 60
35 (1.9)
11 (2.7)
12 (1.8)
2 (2.2)
HPV16 and HPV33 negative (n = 1991)
1325 (73.2)
253 (62.5)
368 (54.3)
45 (49.4)
HPV 16 and HPV 33 positive (n = 25)
14 (0.8)
3 (0.7)
8 (1.3)
0 (−)
Single HPV 33 (n = 57)
23 (1.3)
16 (3.95)
16 (2.4)
2 (2.2)
Multiple HPV 16 (no HPV 33) (n = 375)
178 (9.8)
51 (12.6)
130 (19.2)
16 (17.6)
Multiple HPV 33 (no HPV 16) (n = 49)
25 (1.4)
7 (1.7)
16 (2.4)
1 (1.1)
HPV16 and HPV51 negative (n = 1565)
1190 (65.7)
236 (58.3)
335 (49.4)
40 (44)
HPV16 and HPV51 positive (n = 85)
52 (2.9)
11 (2.7)
20 (2.9)
2 (2.2)
Single HPV 51 (n = 156)
97 (5.4)
23 (5.7)
32 (4.7)
4 (4.4)
Multiple HPV 16 (no HPV 51) (n = 312)
140 (7.7)
43 (10.6)
118 (17.4)
11 (12.1)
Multiple HPV 51 (no HPV 16) (n = 131)
77 (4.2)
17 (4.2)
33 (4.9)
4 (4.4)
HPV16 and HPV52 negative (n = 1598)
1080 (59.6)
209 (51.6)
278 (41)
31 (34.1)
HPV16 and HPV52 positive (n = 157)
64 (3.5)
20 (5)
65 (9.6)
8 (8.8)
Single HPV 52 (n = 219)
141 (7.8)
31 (7.6)
42 (6.2)
5 (5.5)
Multiple HPV 16 (no HPV 52) (n = 240)
128 (7.1)
34 (8.4)
73 (10.8)
5 (5.5)
Multiple HPV 52 (no HPV 16) (n = 280)
152 (8.4)
36 (8.9)
80 (11.8)
12 (13.2)
HPV16 and HPV66 negative (n = 1836)
1273 (70.3)
252 (62.2)
373 (55)
38 (41.8)
HPV16 and HPV66 positive (n = 33)
23 (1.3)
4 (1)
5 (0.8)
1 (1.1)
Single HPV66 (n = 88)
56 (3.1)
10 (2.5)
18 (2.6)
4 (4.4)
Multiple HPV 16 (no HPV 66) (n = 364)
169 (9.3)
50 (12.3)
133 (19.6)
12 (13.2)
Multiple HPV 66 (n = 73)
44 (2.4)
14 (3.5)
9 (1.3)
6 (6.6)
CIN: cervical intraepithelial neoplasia. HPV: human papilloma virus. higher than expected rate by the chi-squared test and post-hoc analysis with Bonferroni correction lower than expected rate by the chi-squared test and post-hoc analysis with Bonferroni correction.
