Research Article
The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study
Table 1
Clinical results of the enrolled women at baseline and at follow-up.
| | Histopathology | hrHPV | Cytology | p16/Ki-67 | p16/MCM2 | Negative,
(n/N %) | 16/18 positive,
(n/N, %) | Other subtypes positive,
(n/N, %) | NILM
(n/N, %) | ASC-us+
(n/N, %) | Negative,
(n/N, %) | Positive,
(n/N, %) | Negative,
(n/N, %) | Positive,
(n/N, %) |
| | Baseline | Not biopsied or normal (N = 758) | 477 (62.9) | 36 (4.7) | 245 (32.3) | 672 (88.7) | 59 (7.8) | 626 (82.6) | 131 (17.3) | 570 (75.2) | 188 (24.8) | | CIN1 (N = 25) | 0 (0.0) | 8 (32.0) | 17 (68.0) | 18 (72.0) | 7 (28.0) | 13 (52.0) | 12 (48.0) | 8 (32.0) | 17 (68.0) | | CIN2+ (N = 22) | 0 (0.0) | 7 (31.8) | 15 (68.2) | 11 (50.0) | 11 (50.0) | 2 (9.1) | 20 (90.9) | 4 (18.2) | 18 (81.8) | | Total (N = 805) | 477 (59.3) | 51 (6.3) | 277 (34.4) | 701 (87.1) | 77 (9.6) | 642 (79.8) | 163 (20.2) | 582 (72.3) | 223 (27.7) |
| | Follow-up | Not biopsied or normal (N = 472) | 377 (79.7) | 11 (2.3) | 84 (17.8) | 396 (83.9) | 33 (7.0) | — | — | — | — | | CIN1 (N = 6) | 0 (0.0) | 1 (16.7) | 5 (83.3) | 1 (16.7) | 4 (66.7) | — | — | — | — | | CIN2+ (N = 7) | 0 (0.0) | 1 (14.3) | 6 (85.7) | 5 (71.4) | 2 (28.6) | — | — | — | — | | Total (N = 485) | 377 (77.7) | 13 (2.7) | 95 (19.6) | 402 (82.9) | 39 (8.0) | — | — | — | — |
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27 women at baseline and 44 at follow-up screening with unsatisfactory cytology are not shown. |
