Research Article
The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study
Table 2
Positive rate of p16/Ki-67, p16/MCM2 and cocktail staining by hrHPV genotyping, cytology, and histopathology at baseline.
| | | p16/Ki-67 | p16/MCM2 | Cocktail | | Negative, n (n/N %) | Positive, n (n/N %) | Negative, n (n/N %) | Positive, n (n/N %) | Negative, n (n/N %) | Positive, n (n/N %) |
| | HrHPV | Negative (N = 477) | 435 (91.2) | 42 (8.8) | 446 (93.5) | 31 (6.5) | 415 (87.0) | 62 (13.0) | | HPV 16/18+ (N = 51) | 26 (51.0) | 25 (49.0) | 16 (31.4) | 35 (68.6) | 14 (27.5) | 37 (72.5) | | Other subtypes+ (N = 277) | 181 (65.3) | 96 (34.7) | 120 (43.3) | 157 (56.7) | 111 (40.1) | 166 (59.9) |
| | Cytology | NILM (N = 701) | 588 (83.9) | 113 (16.1) | 531 (75.7) | 170 (24.3) | 497 (70.9) | 204 (29.1) | | ASC-US (N = 45) | 18 (40.0) | 27 (60.0) | 14 (31.1) | 31 (68.9) | 13 (28.9) | 32 (71.1) | | LSIL (N = 24) | 10 (41.7) | 14 (58.3) | 10 (41.7) | 14 (58.3) | 7 (29.2) | 17 (70.8) | | HSIL+ (N = 8) | 3 (37.5) | 5 (62.5) | 2 (25.0) | 6 (75.0) | 1 (12.5) | 7 (87.5) |
| | Histopathology | Normal/CIN1 (N = 783) | 640 (81.7) | 143 (18.3) | 578 (73.8) | 205 (26.2) | 538 (68.7) | 245 (31.3) | | CIN2 (N = 7) | 1 (14.3) | 6 (85.7) | 2 (28.6) | 5 (71.4) | 1 (14.3) | 6 (85.7) | | CIN3+ (N = 15) | 1 (6.7) | 14 (93.3) | 2 (13.3) | 13 (86.7) | 1 (6.7) | 14 (93.3) |
|
|
†Cocktail staining positive means that either the p16/Ki67 or p16/MCM2 positive. Cytology HSIL + including HSIL and ASC-H. |
