The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study

Table 3

Performance of p16/Ki-67, p16/MCM2 staining, and cytology for triaging hrHPV-positive women in detecting CIN2+ at baseline.

Triage tests	Sensitivity, % (95% CI)	Specificity, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)	AUC (95% CI)
HrHPV-positive women at baseline (n = 328)
Cytology	50.0 (30.7–71.2)	79.7 (74.9–83.9)	15.1 (8.6–25.0)	95.7 (92.4–97.6)	0.65 (0.52, 0.78)
p16/Ki-67	90.9 (72.2–97.5)	67.0 (61.5–72.0)	16.5 (11.0–24.2)	99.0 (96.6–99.7)	0.79 (0.71, 0.87)
p16/MCM2	81.8 (61.5–92.7)	43.1 (37.7–48.7)	9.4 (6.0–14.3)	97.1 (92.7–98.9)	0.63 (0.52, 0.74)
Cocktail staining	90.9 (72.2–97.5)	40.2 (34.9–45.7)	9.9 (6.5–14.7)	98.4 (94.4–99.6)	0.66 (0.56, 0.76)

Cocktail staining positive means that either the p16/Ki-67 or p16/MCM2 positive.