Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility

Table 3

Genotype frequencies of SNPs in TLR genes and their association with NSCLC.

Genotypes	Cases (n = 700)		Controls (n = 700)		OR (95% CI)^a	value
	No	(%)	No	(%)
TLR3 rs5743303
AA	514	73.4	508	72.6
AT	163	23.3	177	25.3	0.89 (0.69–1.15)	0.366
TT	23	3.3	15	2.1	1.46 (0.75–2.86)	0.270
TLR4 rs1927914
AA	225	32.1	233	33.3
AG	351	50.1	346	49.4	0.96 (0.75–1.22)	0.708
GG	124	17.8	121	17.3	0.97 (0.76–1.33)	0.841
TLR4 rs7869402
CC	635	90.7	602	86.0
CT	63	9.0	93	13.3	0.65 (0.46–0.91)	0.013^b
TT	2	0.3	5	0.7	0.38 (0.07–2.01)	0.254
CT + TT	65	9.3	98	14.0	0.63 (0.45–0.89)	0.008^b
TLR4 rs11536891
TT	586	83.7	605	86.4
CT	112	16.0	93	13.3	1.22 (0.90–1.65)	0.203
CC	2	0.3	2	0.3	1.19 (0.90–1.65)	0.862
CT + CC	114	16.3	95	13.6	1.22 (0.90–1.64)	0.200
TLR5 rs1640816
GG	573	81.9	567	81.0
AG	117	16.7	128	18.3	0.85 (0.64–1.23)	0.263
AA	10	1.4	5	0.7	0.97 (0.71–1.33)	0.841
TLR7 rs3853839
Male
G	357	51.0	352	50.3
C	108	15.4	117	16.7	0.94 (0.69–1.28)	0.690
Female
GG	136	19.4	138	19.7
CG	83	11.9	82	11.7	1.01 (0.69–1.49)	0.960
CC	16	2.3	11	1.6	1.40 (0.62–3.15)	0.415

^aAdjusted for age, gender, and smoking status.