Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility

Table 4

The association of the TLR4 rs7869402 variant with NSCLC risk by selected variables.

Variables	Genotypes (cases/controls)			TT + CT/CC model OR (95% CI)^a	value (TT + CT/CC)	CT/CC model OR (95% CI)^a	value (CT/TT)
	CC	CT	TT
Gender
Male	423/399	41/67	1/3	0.58 (0.38–0.87)	0.009	0.58 (0.38–0.89)	0.014
Female	212/203	22/26	1/2	0.78 (0.43–1.41)	0.414	0.65 (0.46–0.91)	0.478
Age
≤60	357/328	28/54	1/4	0.43 (0.27–0.69)	0.001	0.44 (0.27–0.72)	0.001
>60	278/274	35/39	1/1	0.96 (0.59–1.57)	0.868	0.96 (0.59–1.59)	0.881
Smoking status
Nonsmoker	350/436	38/63	1/4	0.74 (0.49–1.13)	0.168	0.77 (0.50–1.19)	0.241
Smoker	285/166	25/30	1/1	0.50 (0.29–0.87)	0.013	0.49 (0.28–0.87)	0.014
Pack year of smoking
≤30	167/94	16/20	1/0	0.46 (0.23–0.92)	0.029	0.42 (0.20–0.86)	0.018
>30	118/72	91/10	0/1	0.44 (0.17–1.14)	0.091	0.48 (0.18–1.27)	0.137
Histological types
Adenocarcinoma	365/602	35/93	2/5	0.62 (0.41–0.92)	0.019	0.61 (0.41–0.93)	0.021
Squamous cell	243/602	27/93	0/5	0.71 (0.44–1.13)	0.145	0.74 (0.46–1.19)	0.214
Other carcinomas	27/602	1/93	0/5	0.23 (0.03–1.70)	0.149	0.24 (0.03–1.79)	0.164

^aData were calculated by unconditional logistic regression and adjusted for age, gender, and smoking status, where they were appropriate.