Identification of Monotonically Differentially Expressed Genes across Pathologic Stages for Cancers

Table 1

Monotonically differentially expressed genes.

Study		0.05	0.1	0.15	0.2
Colon cancer (n = 68)	MI	1 (0/0)	37 (32/0)	78 (81/0)	114 (127/0)
4 stages (I, II, III, and IV) and controls	MD	31 (0/0)	171 (97/0)	245 (157/0)	278 (204/0)
Esophageal cancer (n = 145)	MI	0 (0/0)	119 (0/0)	304 (0/0)	456 (25/0)
4 stages (I, II, III, and IV)	MD	0 (0/0)	13 (0/0)	32 (0/0)	54 (3/0)
NSCLC (n = 104)	MI	0 (0/0)	102 (0/0)	266 (0/0)	342 (0/0)
4 stages (IA, IB, IIA, and IIB)	MD	0 (0/0)	3 (0/0)	7 (0/0)	20 (0/0)

MI: monotonically increasing expressed genes; MD: monotonically decreasing expressed genes; NSCLC: non-small-cell lung cancer. (x/xx): x is the number of MEGs identified by the conventional Kruskal-Wallis method and xx is the number of MEGs identified by the MFSelector method. For example, for the NSCLC application at the significance level of 0.1, the (0/0) entity after 102 means both the conventional method and the MFSelection method identified 0 MI genes.