Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203/HK2 Axis in Esophagal Cancer

Table 2

Univariate analysis of prognostic parameters for survival in EC patients.

Prognostic parameter	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Expression of UCA1 (low vs. high)	3.921	2.323–6.618	<0.001	2.161	1.132–4.127	0.020
Age (≤60vs. > 60)	1.287	0.802–2.065	0.296
Gender (male vs. female)	0.779	0.439–1.383	0.394
Tumor size (≤3 cm vs > 3 cm)	1.437	0.874–2.361	0.153
Smoking status (yes vs. no)	0.942	0,582–1.523	0.806
Alcohol status (yes vs. no)	1,433	0.833–2,360	0.144
Tumor location (lower, middle, vs. upper)	1.082	0.741–1.581	0.682
Lymphatic invasion (yes vs. no)	2.845	1.596–5.071	<0.001	19.646	2.562–150.643	0.004
Distant metastasis (yes vs. no)	5.971	3.496–10.198	<0.001	7.035	3.608–13.717	<0.001
Differentiation (low, moderate, vs. well)	1.059	0.749–1.498	0.746
TNM stage (I + II and III + IV)	1.508	1.164–1.953	0.002	0.069	0.009–0.552	0.012

HR: hazard ratio; CI: confidence interval. The bold number represents the values with significant differences.