Construction of Nomograms for Predicting Lung and Bone Metastases in Patients with Intrahepatic Cholangiocarcinoma and Identification of Patients Who Can Benefit from Chemotherapy

Table 2

Univariate and multivariate logistic regressions of predictors of lung metastasis from ICC patients.

Variables	Univariate logistic		Multivariable logistic
	OR (95% CI)	value	OR (95% CI)	value
Age
<45	1 (reference)
45–65	1.806 (0.637–7.587)	0.333
≥65	1.212 (0.426–5.100)	0.753
Gender
Female	1 (reference)		1 (reference)
Male	2.101 (1.320–3.438)	0.002	2.253 (1.365–3.817)	0.002
Race
White	1 (reference)
Black	0.411 (0.100–1.127)	0.137
Other	0.727 (0.318–1.449)	0.404
Histological grade
Well/moderate	1 (reference)		1 (reference)
Poor/undifferentiated	2.124 (1.357–3.360)	0.001	1.791 (1.094–2.957)	0.021
T stage
T1	1 (reference)		1 (reference)
T2	2.123 (1.206–3.924)	0.012	1.152 (0.618–2.226)	0.664
T3	3.243 (1.634–6.516)	<0.001	1.531 (0.713–3.285)	0.271
T4	1.176 (0.332–3.280)	0.420	0.598 (0.159–1.802)	0.397
Marital status
Single	1 (reference)
Married	1.174 (0.736–1.922)	0.508
N stage
N0	1 (reference)		1 (reference)
N1	2.514 (1.603–3.939)	<0.001	1.611 (0.978–2.641)	0.050
Size
≤5 cm	1 (reference)		1 (reference)
5–10 cm	3.479 (1.790–7.428)	<0.001	3.171 (1.565–7.014)	0.002
>10 cm	8.805 (4.421–19.123)	<0.001	8.133 (3.867–18.563)	<0.001
Intrahepatic metastasis
No	1 (reference)		1 (reference)
Yes	11.734 (6.793–19.980)	<0.001	10.431 (5.768–18.707)	<0.001

ICC: intrahepatic carcinoma, OR: odds ratio, CI: confidence interval.