Construction of Nomograms for Predicting Lung and Bone Metastases in Patients with Intrahepatic Cholangiocarcinoma and Identification of Patients Who Can Benefit from Chemotherapy

Table 3

Univariate and multivariate logistic regressions of predictors of bone metastasis from ICC patients.

Variables	Univariate logistic		Multivariable logistic
	OR (95% CI)	value	OR (95% CI)	value
Age
<45	1 (reference)
45–65	1.095 (0.422–3.744)	0.867
≥65	0.750 (0.288–2.568)	0.597
Gender
Female	1 (reference)		1 (reference)
Male	2.838 (1.676–5.027)	<0.001	2.870 (1.663–5.176)	<0.001
Race
White	1 (reference)
Black	0.319 (0.052–1.039)	0.115
Other	0.743 (0.305–1.543)	0.466
Histological grade
Well/moderate	1 (reference)
Poor/undifferentiated	1.303 (0.803–2.108)	0.280
T stage
T1	1 (reference)
T2	1.101 (0.642–1.920)	0.730
T3	1.354 (0.641–2.727)	0.407
T4	0.396 (0.063–1.365)	0.214
Marital status
Single	1 (reference)		1 (reference)
Married	1.725 (1.010–3.097)	0.055	1.331 (0.7628–2.433)	0.332
N stage
N0	1 (reference)		1 (reference)
N1	1.603 (0.967–2.613)	0.061	1.166 (0.685–1.946)	0.562
Size
≤5 cm	1 (reference)		1 (reference)
5–10 cm	3.574 (1.843–7.620)	<0.001	3.601 (1.834–7.751)	<0.001
>10 cm	5.035 (2.373–11.371)	<0.001	4.551 (2.107–10.434)	<0.001
Intrahepatic metastasis
No	1 (reference)		1 (reference)
Yes	5.748 (2.997–10.485)	<0.001	5.198 (2.632–9.817)	<0.001

ICC: intrahepatic carcinoma, OR: odds ratio, CI: confidence interval.