Prognostic Significance of the Tumor-Stromal Ratio in Invasive Breast Cancer and a Proposal of a New Ts-TNM Staging System
Table 1
Relationship between TSR and major clinicopathological characteristics.
Characteristics
Total, n (%)
Low TSR, n (%)
High TSR, n (%)
value
Age (years)
0.636
≤50
149 (62.1)
69 (60.5)
80 (63.5)
>50
91 (37.9)
45 (39.5)
46 (36.5)
Menopausal status
0.927
Premenopausal
134 (55.8)
64 (56.1)
70 (55.6)
Postmenopausal
106 (44.2)
50 (43.9)
56 (44.4)
Histological type
0.044
Invasive ductal carcinoma
191 (79.6)
97 (85.1)
94 (74.6)
Others
49 (20.4)
17 (14.9)
32 (25.4)
T stage (cm)
0.966
T1 (T ≤ 2)
35 (15.0)
17 (14.9)
18 (14.3)
T2 (2 < T ≤ 5)
162 (67.5)
76 (66.7)
86 (68.2)
T3 (T > 5)
43 (17.5)
21 (18.4)
22 (17.5)
N status
0.327
N negative
109 (45.4)
48 (42.1)
61 (48.4)
N positive
131 (54.6)
66 (57.9)
65 (51.6)
Histological grade
0.302
I
40 (16.7)
15 (13.2)
25 (19.8)
II
141 (58.8)
72 (63.2)
69 (54.8)
III
59 (24.6)
27 (23.6)
32 (25.4)
ER statusa
0.164
Positive
106 (44.2)
45 (39.5)
61 (48.4)
Negative
134 (55.8)
69 (60.5)
65 (51.6)
HER2 geneb
0.943
Amplification
51 (21.3)
24 (21.0)
27 (21.4)
Nonamplification
189 (78.7)
90 (79.0)
99 (78.6)
aER was determined by immunohistochemistry staining according to the guideline [29]; bHER2 gene was determined by fluorescent in situ hybridization (FISH) according to the guideline [30]. BC, breast cancer; T, tumor; N, node; TSR, tumor-stromal ratio; ER, estrogen receptor; HER2, human epidermal growth factor receptor-2.
