Prognostic Significance of the Tumor-Stromal Ratio in Invasive Breast Cancer and a Proposal of a New Ts-TNM Staging System

Table 2

Univariable and multivariable analysis of parameters associated with 5-DFS.

Parameters	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
T stage	2.542 (1.753–3.686)	<0.001	1.583 (1.100–2.280)	0.014
N status	5.035 (2.966–8.545)	<0.001	3.948 (2.302–6.772)	<0.001
Histological grade	4.439 (3.063–6.433)	<0.001	2.825 (1.883–4.236)	<0.001
ER status	0.363 (0.237–0.555)	<0.001	0.567 (0.358–0.897)	0.015
HER2 gene	2.398 (1.541–3.733)	<0.001	1.614 (0.995–2.618)	0.053
TSR	1.610 (1.062–2.440)	0.025	1.742 (1.137–2.669)	0.011

T, tumor; N, node; TSR, tumor-stromal ratio; ER, estrogen receptor; HER2, human epidermal growth factor receptor-2.