ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m⁶A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity

Figure 4

ZC3H13 increases sensitivity to cisplatin in HCC cells. (a, b) Inhibition rates of cisplatin for Hep3B as well as HUH-7 cells with ZC3H13 deficiency through CCK-8 assays. (c) Evaluation of IC50 values of cisplatin for Hep3B as well as HUH-7 cells with ZC3H13 deficiency. (d, e) Inhibition rates of cisplatin in Hep3B as well as HUH-7 cells with ZC3H13 overexpression by CCK-8 assays. (f) Assessment of IC50 values of cisplatin in Hep3B as well as HUH-7 cells with overexpressed ZC3H13. (g–j) TUNEL assays examining the apoptotic levels of Hep3B as well as HUH-7 cells with ZC3H13 deficiency or overexpression following exposure to cisplatin. Magnification, 200×. ; ; and .

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