Oncological Outcomes in Patients with Appendicular Myxofibrosarcomas: A Retrospective Study
Table 2
Relationship between oncological outcomes and 2-year local recurrence-free rates.
Oncological outcomes
2-year LR over total
2-year LRFR (%)
HR
95% CI
value
Tumor type
Myxofibrosarcoma
7/33
79
Gender
Male
4/17
76
2.33
0.24–22.44
0.46
Female
1/12
92
Age
≤60 years old
1/11
91
0.50
0.05–4.80
0.55
>60 years old
4/18
78
Tumor size
≤10 cm
7/20
65
N/A
44–86%
0.02
>10 cm
0/13
100
Margin size
Negative ≤0.1 cm
3/8
63
7.97
0.83–76.79
0.07
Negative >0.1 cm
1/18
94
Surgical margins
Positive
3/7
57
—
—
—
Close margins
3/8
63
0.95
0.19–4.73
0.95
Negative >0.1 cm
1/18
94
0.11
0.01–1.07
0.06
Grouped surgical margins
Positive or close
6/13
54
11.74
1.41–97.74
0.02
Negative >0.1 cm
1/20
95
Tumor depth
Subcutaneous
5/17
71
2.56
0.50–13.21
0.26
Intramuscular
2/16
88
Tumor character
Well-circumscribed
2/18
89
0.30
0.06–1.54
0.15
Infiltrative
5/15
67
Re-resection intraoperatively†
Re-resection done
2/4
50
N/A
1–99%
0.19
Re-resection not done
0/3
0
Re-resection postoperativelyˆ
Re-resection done
0/4
100
N/A
100%
0.07
Re-resection not done
2/3
67%
Adjuvant therapy
Chemotherapy and radiotherapy
0/17
100%
N/A
100%
0.001
Chemotherapy alone
3/4
25%
Radiotherapy alone
2/8
75%
No treatment
2/4
50%
Note. LRFR = 2-year local recurrence-free rate; LR = local recurrence; HR = hazard ratio; CI = confidence interval. Close margins = negative margins ≤0.1 cm; the Kaplan–Meier log-ranked test was used to assess statistical significance; †re-resections were done intraoperatively due to positive intraoperative pathology report; ˆre-resections were done postopearatively due to positive final pathology report.
