Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines

<div>Cotreatment of gilteritinib and HHT impaired the MMP and activated an intrinsic apoptotic pathway. (a, b) Percentage of JC-1 monomers. MV4-11 cells (a) and Molm13 cells (b) were given a treatment of gilteritinib and/or HHT for 24 hours. The cells treated with DMSO were used as a control group. (c, d) Western blot analysis of PARP, cleaved PARP, Mcl-1, Bcl-2, Bax, and Bak in treated MV4-11 cells (c) and Molm13 cells (d). 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Journal of Oncology

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Figure 2

Figure 2: Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines 

Figure 2 | Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines 