Identifying Clinicopathological Risk Factors of the Regional Lymph Node Metastasis in Patients with T_1-2 Mucinous Breast Cancer: A Population-Based Study

Table 2

Univariate and multivariate logistic regression analyses of predictive factors associated with regional LNM in patients with T_1-2 pure mucinous breast cancer.

Variables	Subgroup	Univariable		Multivariable
		Hazard ratio		Hazard ratio
Age	<45	Reference	<0.001	Reference	0.001
	≥45 and <60	0.69 (0.42–1.13)		0.68 (0.40–1.14)
	≥60 and <70	0.37 (0.21–0.63)		0.44 (0.25–0.77)
	≥70	0.28 (0.16–0.48)		0.34 (0.19–0.60)
Tumor size (mm)	>0 and ≤5	Reference	<0.001	Reference	<0.001
	>5 and ≤10	0.86 (0.16–4.51)		1.04 (0.19–5.54)
	>10 and ≤20	5.17 (1.24–21.48)		6.12 (1.44–25.98)
	>20 and ≤50	13.84 (3.36–56.93)		15.29 (3.62–64.49)
Race	White	Reference	0.008	Reference	0.004
	Black	1.91 (1.23–2.96)		1.68 (1.05–2.69)
	^※Others	0.83 (0.47–1.45)		0.52 (0.29–0.94)
Location	^¶Central	Reference	0.749	—	—
	Upper	1.11 (0.57–2.16)		—	—
	Lower	1.06 (0.52–2.16)		—	—
	Axillary tail	3.15 (0.59–16.72)		—	—
	Overlapping	1.13 (0.56–2.26)		—	—
^＆Grade	I	Reference	<0.001	Reference	0.001
	II	2.50 (1.76–3.55)		1.94 (1.34–2.80)
	III	3.49 (1.79–6.83)		1.98 (0.95–4.15)
Laterality	Right	Reference	0.808	—	—
	Left	0.96 (0.68–1.33)		—	—
Tumor subtype	Luminal A	Reference	<0.001	Reference	0.029
	Luminal B	2.88 (1.67–4.95)		2.17 (1.19–3.96)
	TNBC	4.74 (1.24–18.09)		3.06 (0.73–12.86)
	HER2 enriched	1.68 (0.38–7.45)		2.38 (0.46–12.09)

Notes: ^※Others: defined as the Asian/Pacific Islander and American Indian/Alaska Native. Bold values indicate statistical significance (). ^¶Central: central portion of breast combined with nipple; ^＆grade I: well differentiated, grade II: moderately differentiated, and grade III: poorly differentiated. LNM: lymph node metastasis; TNBC: triple-negative breast cancer; Her-2: human epidermal growth factor receptor-2.