DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway

Figure 1

DOK7 is significantly downregulated in breast cancer tissues and is associated with clinical outcomes. (a) The mRNA levels of DOK7 in 68 paired normal and breast cancer tissues were evaluated using qRT-PCR assay. The mRNA levels of DOK7 were shown as log₂ fold-change vs adjacent tissues. (b) Expression of DOK7 in 68 paired normal and breast cancer tissues with different TNM stages (I/II stage or III/V stage) was evaluated using qRT-PCR assay. (c) The mRNA levels of DOK7 in 68 paired normal and breast cancer tissues with different T stage statuses (T1 or T2/3) were measured using qRT-PCR assay. (d) The mRNA levels of DOK7 in 68 paired normal and breast cancer tissues with different lymph node metastases (N0 or N1/2/3) were checked using qRT-PCR assay.  < 0.05;  < 0.01.

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