DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway

Figure 5

DOK7 inhibits tumor growth and metastasis of breast cancer in vivo. (a) DOK7-overexpressed and controlled MDA-MB-231 cells were injected into the mammary fad pads of nude mice. The tumor sizes (b) and tumor weights (c) in the control group and DOK7 overexpression group were calculated. (d) The expression of Ki-67 and PCNA in the control group and DOK7 overexpression group was evaluated using immunohistochemistry assay. (e) DOK7-overexpressed and controlled MDA-MB-231 cells were injected into the tail vein. (f) The number of lung metastatic nodules of mice was calculated. Scale bar = 50 µm in (d).  < 0.05; ns, no significant.

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