ARHGAP11A Promotes the Malignant Progression of Gastric Cancer by Regulating the Stability of Actin Filaments through TPM1

Figure 1

Expression of ARHGAP11A in gastric cancer patients and its relationship with prognosis. (a) Bioinformatic analysis showed that ARHGAP11A was highly expressed in various types of cancer tissues. (b) ARHGAP11A expression was increased in gastric cancer tissues compared with normal tissues. (c) Gene chip analysis of the expression profile showed that ARHGAP11A was highly expressed in gastric cancer tissues. (d) qRT-PCR was used to detect the expression of ARHGAP11A mRNA in gastric cancer and normal tissues. (e) Western blot was performed to detect the expression of the ARHGAP11A protein in gastric cancer and normal tissues. (f) Immunohistochemistry method detects weak and strong positive expression of ARHGAP11A in gastric cancer tissues. The scale bar indicates 200 μm. (g) Quantitative analysis of ARHGAP11A expression in gastric cancer and corresponding adjacent tissues after immunohistochemical staining by comparison of H scores. (h) Kaplan-Meier survival analysis was performed on 432 patients with gastric cancer. (i) Comparison of the number of gastric cancer patients with different differentiation levels in the high and low ARHGAP11A expression groups; the difference was statistically significant. .

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