Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas

<div>Chidamide alone or chidamide and radiation combinational treatment upregulates miR-375 in NCI-H2170 and NCI-H226 cells. (a) miRNA microarray to identify the differential expressed miRNAs in NCI-H2170 and NCI-H226 cells subjected to radiation (2 Gy), chidamide (300 nM), and their combinational treatment. (b) Real-time PCR to determine the expression of miR-375 in NCI-H2170 and NCI-H226 cells with indicated treatment. 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Journal of Oncology

fig3

Figure 3

Figure 3: Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas 

Figure 3 | Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas 