Identification and Validation of Three PDAC Subtypes and Individualized GSVA Immune Pathway-Related Prognostic Risk Score Formula in Pancreatic Ductal Adenocarcinoma Patients

Figure 5

(a) Based on TCGA-PDAC data, absolute shrinkage and selection operator (LASSO) coefficient profiles were exerted. (b) Best penalization coefficient (λ) by threefold validation according to partial likelihood deviance. (c) The significant gene sets and pathways after LASSO regression with the risk coefficient. (d–f) Survival analysis of each gene set and pathway on TCGA-PDAC cohort. (g–i) Survival analysis of each gene set and pathway on the GSE28735 and GSE62452 cohorts. (j) Survival analysis of the calculated risk formula on TCGA-PDAC cohort. (k) Survival analysis of the calculated risk formula on GSE28735 and GSE62452 cohort.

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