All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer

Figure 1

ATRA enhanced the inhibitory effects of 5-Fu on progression of HCT116 cells and induced cell apoptosis in a concentration-dependent manner. (a) Cell viability measured by MTT assay ( < 0.05). (b) Cell apoptosis after treating with indicated reagents. (c) The level of proteins related to cell apoptosis. (d) Migration of HCT116 cells after indicated treatment ( < 0.05). (e) Invasion of HCT116 cells after indicated treatment ( < 0.05).