All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer

Figure 2

MiR-378c is downregulated in CRC and is positively regulated by treatment of 5-FU combined with ATRA significantly. (a) The expression level of miR-378c in CRC according to ENCORI database. (b) The mRNA level of miR-378c in CRC tissues and para-carcinoma tissues (N = 15) was detected by qRT-PCR ( < 0.05). (c) The relationship between miR-378c and 5-FU in addition to ATRA ( < 0.05).

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