All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer

Figure 4

(a) E2F7 was the direct target of miR-378c. (b) The luciferase activity of wild-type E2F7 but not mutant E2F7 was regulated by miR-378c mimic ( < 0.05). (c) E2F7 was downregulated by miR-378c mimic but upregulated by miR-378c inhibitor ( < 0.05).

(a)

(b)

(c)