All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer

Figure 5

E2F7 is upregulated in CRC and is negatively regulated by treatment of 5-FU combined with ATRA significantly. (a) The level of E2F7 was lower dramatically in CRC, according to GEPIA database. (b) The mRNA level of E2F7 in CRC tissues and para-carcinoma tissues was detected by qRT-PCR (N = 15,  < 0.05). (c) The relationship between E2F7 and 5-FU in addition to ATRA ( < 0.05).

(a)

(b)

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