Prognostic Implications of Immune-Related Gene Pairs Signatures in Bladder Cancer

Table 3

Univariate and multivariate analyses of prognostic factors in the TCGA data set and independent validation data set.

Characteristics	Univariate			Multivariate
	Hazard ratio	CI95	value	Hazard ratio	CI95	value
TCGA dataset (OS)
Riskscore	3.95	3.12–4.99	<0.0001	3.39	2.65–4.34	<0.0001
Age	1.85	1.25–2.73	0.0020	1.5	1.01–2.22	0.0452
Gender	1.19	0.86–1.66	0.2932	NA	NA	NA
Stage_T	1.69	1.37–2.09	0.0360	1.35	1.07–1.71	0.0104
Stage_N	1.15	1.05–1.25	0.0015	1.18	1.07–1.3	0.0011
Stage_M	1.11	1.01–1.23	<0.0001	1.01	0.91–1.13	0.7855
GSE13507 dataset (OS)
Riskscore	1.58	1.05–2.37	0.0270	1.54	1.01–2.35	0.0462
Age	3.9	1.86–8.19	0.0003	3.62	1.72–7.62	0.0007
Gender	1.56	0.88–2.77	0.1290	NA	NA	NA
Stage_T	1.03	0.89–1.2	0.7038	NA	NA	NA
Stage_N	2.71	1.99–3.69	<0.0001	2.19	1.52–3.13	<0.0001
Stage_M	9.9	4.38–22.37	<0.0001	2.62	1.05–6.54	0.0397
GSE13507 dataset (DSS)
Riskscore	2.24	1.23–4.08	0.0087	1.83	1–3.36	0.0504
Age	3.12	1.09–8.9	0.0336	3.18	1.08–9.34	0.0355
Gender	2.1	0.97–4.54	0.0600	NA	NA	NA
Stage_T	1.34	1.09–1.63	0.0046	1.34	1.06–1.7	0.0155
Stage_N	3.29	2.36–4.58	<0.0001	2.55	1.77–3.69	<0.0001
Stage_M	13.12	5.28–32.6	<0.0001	2.52	0.92–6.85	0.0708