NK Cell Subpopulation Is Altered and the Expression of TLR1 and TLR9 Is Decreased in Patients with Acute Lymphoblastic Leukemia

Figure 2

Determination of NK cell subpopulations using the CD56/CD16 phenotype. (a) Histograms of subpopulations of NK cells in the controls and ALL patients in the peripheral blood and in the bone marrow of ALL patients; peripheral blood results for a single control and a single patient and bone marrow results for a single patient are displayed. NK^bright cells can be subdivided into (I) NK [CD56^high CD16−] and (II) NK [CD56^high CD16+]; NK^dim cells can be subdivided into (III) NK [CD56l^ow CD16−], (IV) NK [CD56^low CD16+], and (V) NK [CD56− CD16+] cells. (b) Graph showing the percentage (median ± ranges) in each subpopulation (IV) with respect to the total NK^total count [CD14−, CD19−, CD3−, CD56+, and CD16±] in the peripheral blood of 10 controls and 9 patients with ALL and in the bone marrow of 10 patients with ALL; the medians of each of the groups are shown. . NK, natural killer; ALL, acute lymphoblastic leukemia.

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