CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells

Figure 6

CWHM-1008 induced apoptosis of LUAD cell in vivo. (a) Body weight gain, food consumption, and organ coefficient results of mice treated orally with CWHM-1008. Oral administration of 300 mg/kg for one time and related data were collected 14 days after treatment. (b) Tumor volume curve of subcutaneous A549 tumor-bearing mice after receiving various dose of CWHM-1008 treatments. (c) Representative images for subcutaneous xenograft tumors; n = 4. (d) Tumor weights at time of sacrifice. Representative immunohistochemical pictures of Ki67 ((e), left) and TUNEL ((f), left) for each treatment group. Scale bar = 50 μm. The scatter plot graph on the right shows the immunohistochemical score for Ki67 and TUNEL for each treatment groups. Data are presented as the mean ± SD, n = 4. and ; ns, not significant.

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