MicroRNA Expression Profiling of Lung Cancer with Differential Expression of the RON Receptor Tyrosine Kinase

Figure 3

miRNA gene interaction network. Red boxes represent miRNAs, and blue square nodes represent the predicted target genes. Edges show the inhibitory effect of a miRNA to its predicted targets. Overexpressed miRNAs hsa-miR-1290 and hsa-miR-33a-5p show the most target mRNAs. hsa-miR-27b-3p and hsa-miR-21-5p have the highest degree of connectivity among underexpressed miRNAs. Degree refers to the contribution of one miRNA to the target genes around it or the contribution of one gene to the miRNAs around it. The key miRNAs and genes in the network always have the highest degrees of connectivity.