The Clinical Characteristics and Prognostic Nomogram for Head and Neck Cancer Patients with Bone Metastasis

Table 1

Demographic and clinical characteristics of HNSCC patients with bone metastases.

Variables	Training cohort		Validation cohort
	N = 230		N = 96
	n	%	n	%
Age
<47	34	14.8	14	14.6
47–72	157	68.3	63	65.6
>72	39	17.0	19	19.8
>66	733
Race
Black	44	19.1	25	26.0
Other	30	13.1	14	14.6
White	156	67.8	57	59.4
Sex
Female	53	23.0	26	27.1
Male	177	77.0	70	72.9
Primary site
Oropharynx	74	32.2	26	27.1
Hypopharynx	7	3.0	7	7.3
Larynx	28	12.2	7	7.3
Nasopharynx	59	25.7	24	25.0
Oral cavity	62	27.0	32	33.3
Histological types
Others	59	25.7	25	26.1
Squamous cell carcinoma	171	74.3	71	73.9
Grade
I	6	2.6	3	3.1
II	60	26.1	25	26.0
III	126	54.8	51	53.1
IV	38	16.5	17	17.7
T stage
T1	35	15.2	10	10.4
T2	41	17.8	20	20.8
T3	52	22.6	24	25.0
T4	102	44.3	42	43.8
N stage
N0	34	14.8	14	14.6
N1	50	21.7	25	26.0
N2	126	54.8	44	45.8
N3	20	8.7	13	13.6
Surgery
No	187	81.3	76	79.2
Yes	43	18.7	20	20.8
Chemotherapy
No	83	36.1	32	33.3
Yes	147	63.9	64	66.7
Radiotherapy
No	105	45.7	35	36.5
Yes	125	54.3	61	63.5
Liver metastasis
No	184	80.0	82	85.4
Yes	46	20.0	14	14.6
Brain metastasis
No	216	93.9	92	95.8
Yes	14	6.1	4	4.2
Lung metastasis
No	161	70.0	66	68.8
Yes	69	30.0	30	31.2
Insurance status
No	25	10.9	13	13.5
Yes	205	89.1	83	86.5
Marital
No	120	52.2	49	51.0
Yes	110	47.8	47	49.0