Research Article
The Clinical Characteristics and Prognostic Nomogram for Head and Neck Cancer Patients with Bone Metastasis
Table 2
Univariate and multivariate Cox regression analysis in HNC patients with bone metastases.
| | Univariate Cox analysis | Multivariate Cox analysis | HR | 95%CI | | HR | 95%CI | |
| Age | | | | | | | | | <47 | 1 | | | | 1 | | | | 47–72 | 2.061 | 1.319 | 0.001 | 0.043 | 1.496 | 0.933 | 2.399 | 0.095 | >72 | 3.402 | 2.000 | 5.788 | ≤0.001 | 2.203 | 1.248 | 3.888 | 0.006 |
| Race | | | | | | | | | Black | 1 | | | | | | | | Other | 0.691 | 0.412 | 1.159 | 0.161 | | | | | White | 0.904 | 0.634 | 1.291 | 0.580 | | | | |
| Sex | | | | | | | | | Female | 1 | | | | | | | | Male | 1.150 | 0.825 | 1.604 | 0.409 | | | | |
| Primary site | | | | | | | | | Oropharynx | 1 | | | | 1 | | | | Hypopharynx | 2.357 | 1.076 | 5.162 | 0.032 | 2.183 | 0.990 | 4.813 | 0.053 | Larynx | 1.056 | 0.673 | 1.657 | 0.814 | 0.965 | 0.613 | 1.522 | 0.880 | Nasopharynx | 0.432 | 0.293 | 0.637 | ≤0.001 | 0.549 | 0.363 | 0.829 | 0.004 | Oral cavity | 0.902 | 0.634 | 1.283 | 0.565 | 0.726 | 0.499 | 1.057 | 0.095 |
| Histological types | | | | | | | | | Others | 1 | | | | | | | | Squamous cell carcinoma | 1.318 | 0.950 | 1.828 | 0.099 | | | | |
| Grade | | | | | | | | | I | 1 | | | | | | | | II | 0.902 | 0.386 | 2.108 | 0.812 | | | | | III | 0.802 | 0.353 | 1.825 | 0.599 | | | | | IV | 0.540 | 0.223 | 1.309 | 0.173 | | | | |
| T stage | | | | | | | | | T1 | 1 | | | | | | | | T2 | 1.539 | 0.945 | 2.505 | 0.083 | | | | | T3 | 1.548 | 0.971 | 2.468 | 0.066 | | | | | T4 | 1.326 | 0.871 | 2.019 | 0.189 | | | | |
| N stage | | | | | | | | | No | 1 | | | | | | | | N1 | 1.255 | 0.784 | 2.008 | 0.344 | | | | | N2 | 1.170 | 0.771 | 1.774 | 0.462 | | | | | N3 | 1.253 | 0.683 | 2.299 | 0.466 | | | | |
| Surgery | | | | | | | | | No | 1 | | | | | | | | Yes | 0.749 | 0.524 | 1.070 | 0.113 | | | | |
| Chemotherapy | | | | | | | | | No | 1 | | | | 1 | | | | Yes | 0.526 | 0.396 | 0.700 | ≤0.001 | 0.579 | 0.422 | 0.795 | ≤0.001 |
| Radiotherapy | | | | | | | | | No | 1 | | | | | | | | Yes | 0.923 | 0.699 | 1.218 | 0.572 | | | | |
| Liver metastasis | | | | | | | | | No | 1 | | | | | | | | Yes | 1.106 | 0.789 | 1.550 | 0.559 | | | | |
| Brain metastasis | | | | | | | | | No | 1 | | | | | | | | Yes | 1.179 | 0.656 | 2.119 | 0.582 | | | | |
| Lung metastasis | | | | | | | | | No | 1 | | | | 1 | | | | Yes | 1.552 | 1.149 | 2.095 | 0.004 | 1.427 | 1.052 | 1.936 | 0.022 |
| Insurance status | | | | | | | | | No | 1 | | | | | | | | Yes | 0.880 | 0.565 | 1.371 | 0.572 | | | | |
| Marital | | | | | | | | | No | 1 | | | | | | | | Yes | 0.780 | 0.591 | 1.031 | 0.081 | | | | |
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