Research Article

The Clinical Characteristics and Prognostic Nomogram for Head and Neck Cancer Patients with Bone Metastasis

Table 2

Univariate and multivariate Cox regression analysis in HNC patients with bone metastases.

Univariate Cox analysisMultivariate Cox analysis
HR95%CIHR95%CI

Age
<4711
47–722.0611.3190.0010.0431.4960.9332.3990.095
>723.4022.0005.788≤0.0012.2031.2483.8880.006

Race
Black1
Other0.6910.4121.1590.161
White0.9040.6341.2910.580

Sex
Female1
Male1.1500.8251.6040.409

Primary site
Oropharynx11
Hypopharynx2.3571.0765.1620.0322.1830.9904.8130.053
Larynx1.0560.6731.6570.8140.9650.6131.5220.880
Nasopharynx0.4320.2930.637≤0.0010.5490.3630.8290.004
Oral cavity0.9020.6341.2830.5650.7260.4991.0570.095

Histological types
Others1
Squamous cell carcinoma1.3180.9501.8280.099

Grade
I1
II0.9020.3862.1080.812
III0.8020.3531.8250.599
IV0.5400.2231.3090.173

T stage
T11
T21.5390.9452.5050.083
T31.5480.9712.4680.066
T41.3260.8712.0190.189

N stage
No1
N11.2550.7842.0080.344
N21.1700.7711.7740.462
N31.2530.6832.2990.466

Surgery
No1
Yes0.7490.5241.0700.113

Chemotherapy
No11
Yes0.5260.3960.700≤0.0010.5790.4220.795≤0.001

Radiotherapy
No1
Yes0.9230.6991.2180.572

Liver metastasis
No1
Yes1.1060.7891.5500.559

Brain metastasis
No1
Yes1.1790.6562.1190.582

Lung metastasis
No11
Yes1.5521.1492.0950.0041.4271.0521.9360.022

Insurance status
No1
Yes0.8800.5651.3710.572

Marital
No1
Yes0.7800.5911.0310.081